Dear Colleagues and Friends,
Join the next IUIS-Frontiers live webinars on COVID-19 with Eric Vivier on June 22, and Salim Karim on June 29! IUIS and Frontiers have collaborated on a series of weekly, expert commentaries and scientific webinars to accelerate the development of novel diagnostics, therapeutics, and vaccines. You can watch the previous webinars on-demand at iuis.org/webinars. Get insights from Rino Rappuoli, Giuseppe Ippolito, Eleanor Fish, Rachel Humphrey, Andreas Radbruch, Mihai Netea, Sharon Lewin, Katherine Kedzierska, Donna Farber and Lisa Ng! We look forward to seeing you at our next live webinars!
Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis
Date: June 22, 2020
Time: 15:00 (CEST)
Eric Vivier provides a longitudinal analysis of immune responses, including immune cell phenotyping and assessments of the soluble factors present in the blood and broncho-alveolar lavage fluid (BALF) of patients at various stages of COVID-19 severity: paucisymptomatic, pneumonia and acute respiratory distress syndrome (ARDS). He reports an increase in soluble C5a levels proportional to COVID-19 severity and high levels of C5aR1 expression in blood and pulmonary myeloid cells, supporting a role for the C5a-C5aR1 axis in the pathophysiology of ARDS. Anti-C5aR1 therapeutic monoclonal antibodies (mAbs) prevented C5a-mediated human myeloid cell recruitment and activation, and inhibited acute lung injury (ALI) in human C5aR1 knockin mice. These results support C5a-C5aR1 axis blockade as a means of limiting myeloid cell infiltration in damaged organs and preventing the excessive lung inflammation and endothelialitis associated with ARDS in COVID-19 patients.
This webinar will be moderated by Dr. Abdallah Badou, Professor of Immunology at the Faculty of Medicine and Pharmacy, University Hassan II of Casablanca, Morocco.
REGISTER HERE: WEBINAR ASSOCIATION OF COVID-19 INFLAMATION:
COVID-19 in South Africa
Date: June 29, 2020
Time: 16:00 (CEST)
Prof. Salim Abdool Karim, will give us a detailed and scientific overview of the development of COVID-19 in South Africa. Since the first case of COVID-19 on 5 March 2020, the epidemic grew exponentially with a doubling time of 2 days for the first 3 weeks until the effects of state-initiated interventions impacted reducing the doubling time to 15 days. The National response, which comprises 8 stages aims to flatten the curve. Stage 6 of the response on clinical care has provided new insights on the immune response, the role of the cytokine storm and the impact of dexamethasone on reducing mortality. The spectrum of Covid-19 disease from head to toe has transformed our initial understanding of Covid-19 as a respiratory distress syndrome. The webinar will be moderated by Clive Gray, Professor and Chair, Division of Immunology in the Department of Pathology and Director of the Laboratory for Tissue Immunology at the NHLS/Groot Schuur Hospital labs.
REGISTER HERE: WEBINAR COVID-19 IN SOUTH AFRICA: