Dear Colleagues and Friends,
Join the next IUIS-Frontiers live webinar on COVID-19 on July 31 with Elizabeth Mann and Madhvi Menon!
IUIS and Frontiers have collaborated on a series of weekly, expert commentaries and scientific webinars to accelerate the development of novel diagnostics, therapeutics, and vaccines.
We are looking forward to seeing you at our next live webinar!
Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis
Date: July 31, 2020
Time: 16:00 (CEST)
Elizabeth Mann and Madhvi Menon will discuss findings from their recent longitudinal immune profiling study surveying admitted COVID-19 patients across four hospitals in Manchester at the height of the pandemic in the UK. They find key immune signatures that track with disease severity and can potentially be used to identify patients that are destined for intensive care upon admission that are destined for intensive care. They also determine how immune responses change throughout the course of the disease course and how this differs in patients with milder diseases who recovered compared with patients who went go on to become severe/critical. PRESENTER
Elizabeth Mann obtained her PhD from Imperial College London in 2010 studying tissue specificity of human dendritic cells in the laboratory of Professor Stella Knight. Her postdoctoral studies at Johns Hopkins University in Baltimore (with Dr Xuhang Li) and the University of Glasgow (with Professor Simon Milling) investigated mechanisms by which intestinal immune responses are dysregulated in inflammatory bowel disease, and how gut immunity is shaped by local factors including the gut microbiota. Mann established her own research group in 2017 through a Wellcome Trust and Royal Society-funded Henry Dale Fellowship at the University of Manchester, and is currently investigating how mucosal immune responses are regulated by the local environment in the intestine, lungs and reproductive tract.
Madhvi Menon is a Presidential Research Fellow at the University of Manchester investigating mechanisms of B cell dysfunction in chronic inflammatory disorders. Prior to this, she completed her postdoctoral studies at Harvard Medical School, identifying inflammatory pathways contributing to age-related macular degeneration, and at University College London, investigating how gut pathology contributes to the pathogenesis of rheumatoid arthritis. She obtained her PhD in Immunology from University College London in 2015 studying the crosstalk between B cells and plasmacytoid dendritic cells in systemic lupus erythematosus.
After gaining a PhD from Cambridge University studying inflammatory responses in vascular endothelial cells, Dr Ager moved to Professor Judah Folkman’s laboratory at Harvard to train in microvascular endothelial cell biology. She then joined Professor Bill Ford’s laboratory in Manchester to study the regulation of lymphocyte trafficking by high endothelial venules (HEV) where she gained a non-clinical MRC Senior Fellowship before moving to the MRC National Institute for Medical Research. The focus of the Ager lab has been the molecular basis of lymphocyte-HEV recognition.
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