IMPAIRMENT OF THE IMMUNOLOGICAL AND NEUROLOGICAL SYNAPSES BY RESPIRATORY VIRUSES: IMPLICATIONS FOR VACCINES DESIGN
August 31, 2020. Time: 16:00 h. BERLIN; 10:00 h. CHILE; 9:00 h. MEXICO City
Dr. Alexis Kalergis obtained his MSc and PhD in Microbiology and Immunology from the Albert Einstein College of Medicine, New York, U.S.A., and is currently Full Professor at the Department of Molecular Genetics and Microbiology, School of Biological Sciences and the Department of Endocrinology, School of Medicine, at the Pontificia Universidad Católica de Chile, visiting Faculty at the Albert Einstein College of Medicine in New York, the University of Nantes in France and the University of Iowa, U.S.A. Dr. Kalergis is Founder and Director of the Millennium Institute on Immunology and Immunotherapy, appointed as a Center of Excellence by the Federation of Clinical Immunology Societies and committed to transfer basic knowledge into prevention, diagnosis and treatment of pathologies of Health priority in Latin America.
His research group has focused on molecular interactions regulating the synapse between T cells and dendritic cells, and their role on immunity against pathogens and tumors. Relevant findings on the inhibition of the immunological synapse as a major virulence factor of respiratory viruses and alterations on the blood brain barrier upon infection, have led Kalergis to generate novel vaccine approaches that strengthen T-DC synapses to induce protective immunity while preventing CNS damage. Of note, they developed a vaccine against Respiratory Syncytial Virus, which resulted effective and safe from the Phase I clinical trial conduction. Kalergis Laboratory has now designed a vaccine for SARS-CoV-2, which is currently in preclinical evaluation.
COORDINATOR: Rosana Pelayo, Doctor in Biomedical Sciences -Immunology- from the National Autonomous University of Mexico, trained with Paul W. Kincade at the Immunobiology and Cancer Program, OMRF, USA. She currently holds a Principal Investigator position in the Mexican Institute for Social Security, Puebla, Mexico, where leads the Oncoimmunology Laboratory. Dr. Pelayo is Past-President of the Mexican Society of Immunology and Vice-Chair of the IUIS Education Committee.